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Prenatal exposure to unconventional oil and gas operation chemical mixtures altered mammary gland development.

PMID:  Endocrinology. 2018 Mar 1 ;159(3):1277-1289. PMID: 29425295 Abstract Title:  Prenatal Exposure to Unconventional Oil and Gas Operation Chemical Mixtures Altered Mammary Gland Development in Adult Female Mice. Abstract:  Unconventional oil and gas (UOG) operations, which combine hydraulic fracturing (fracking) and directional drilling, involve the use of hundreds of chemicals, including many with

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Orally administered nicotine effects on rat urinary bladder proliferation and carcinogenesis.

PMID:  Toxicology. 2018 Apr 1 ;398-399:31-40. Epub 2018 Mar 6. PMID: 29501575 Abstract Title:  Orally administered nicotine effects on rat urinary bladder proliferation and carcinogenesis. Abstract:  Tobacco smoking is a major risk factor for human cancers including urinary bladder carcinoma. Cigarette smoke inhalation in mice and orally administered nicotine in rats and mice

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Nicotine upregulates FGFR3 and RB1 expression and promotes non-small cell lung cancer cell proliferation.

PMID:  Biomed Pharmacother. 2018 May ;101:656-662. Epub 2018 Mar 22. PMID: 29518612 Abstract Title:  Nicotine upregulates FGFR3 and RB1 expression and promotes non-small cell lung cancer cell proliferation and epithelial-to-mesenchymal transition via downregulation of miR-99b and miR-192. Abstract:  BACKGROUND: Tobacco smoke is by far the greatest risk factor for non-small-cell lung cancer (NSCLC).

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Cigarette smoke constituents cause endothelial nitric oxide synthase dysfunction.

PMID:  Nitric Oxide. 2018 Jun 1 ;76:113-121. Epub 2018 Mar 7. PMID: 29524646 Abstract Title:  Cigarette smoke constituents cause endothelial nitric oxide synthase dysfunction and uncoupling due to depletion of tetrahydrobiopterin with degradation of GTP cyclohydrolase. Abstract:  Cigarette smoking (CS) is a well-established risk factor for cardiovascular disease (CVD). Endothelial dysfunction (ED) with

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